Changes of Activated T Cell Disfunction in Children with Refractory Mycoplasma Pneumoniae Pneumonia
- VernacularTitle:难治性肺炎支原体肺炎患儿T细胞活化功能状态的变化
- Author:
yong, YANG
;
yu, WANG
;
zong-bo, CHEN
- Publication Type:Journal Article
- Keywords:
pneumonia,mycoplasma,refractory;
T-cell;
activated disfunction
- From:Journal of Applied Clinical Pediatrics
2006;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study disfunction of activated T cell from peripheral blood and explore its role on pathogenesis in patients with refractory mycoplasma pneumoniae pneumonia (MPP).Methods T cell subsets and expression of membrane molecule on activated T cell in peripheral blood were measured in 26 refractory MPP patients by using immunofluorescence and flowcytometry,and compared with those of 18 control healthy children.Results The percentage of CD4~+ cell from peripheral blood in refractory MPP children was significantly lower than that in control group(P0.05).Conclusions There are disfunctions of T cell in refractory MPP patients in acute period,and the abnormal T cell activated disfunction may play an important role on pathogenesis.
