Influence of Mild Hypothermia on Serum ?-Endorphin,Neuron-Specific Enolase in Children with Severe Viral Encephalitis
- VernacularTitle:亚低温对重症病毒性脑炎患儿血清?-内啡肽及神经元特异性烯醇化酶的影响
- Author:
qiang, LI
;
yue-yan, HUANG
;
xia-jing, CHEN
- Publication Type:Journal Article
- Keywords:
mild hypothermia;
encephalitis,viral;
?-endorphin;
neuron-specific enolase
- From:Journal of Applied Clinical Pediatrics
2006;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of mild hypothermia on serum ?-endorphin(?-EP),neuron-specific enolase(NSE) and its protection to encephalon in children with severe viral encephalitis.Methods Fifty-six cases with severe viral encephalitis were divided into mild hypothermia group(30 cases) and regular treatment group(26 cases).Regular treatment group was given combined therapy such as decreasing intracranial pressure,antiviral therapy,supportive and symptomatic treatment.While mild hypothermia group was given mild hypothermia treatment besides regular treatment,and the change of serum ?-EP,NSE before treatment and the first day,5~th and 10~th day after treatment in the two groups were determined.Results There were no significant difference of serum ?-EP,NSE before treatment and in the first day after treatment,while it decreased in 5~th and 10~th day after treatment.Serum ?-EP,NSE in mild hypothermia group were significantly lower than those of regular treatment group(P
