The Effect of NK-1 Receptor Antagonist on the Enhanced Response to Bradykinin by Mustard Oil Treatment of the Rat Uterus.
- Author:
Joong Yol NA
1
;
Ji Won PARK
;
Seung Kil HONG
Author Information
1. Department of Obstetrics and Gynecology, School of Medicine, Korea University, Korea.
- Publication Type:Original Article
- Keywords:
Substance P;
Bradykinin;
Uterine inflammation
- MeSH:
Action Potentials;
Animals;
Bradykinin*;
Female;
Humans;
Hypersensitivity;
Inflammation;
Mustard Plant*;
Negotiating;
Rats*;
Receptors, Neurokinin-1*;
Substance P;
Uterine Artery;
Uterus*
- From:Korean Journal of Obstetrics and Gynecology
2003;46(7):1325-1331
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To find out wheather the substance P takes part in the pain mediating system of uterus, and to ascertain the role of substance P in the hypersensitivity of hypogastric nerve to bradykinin during the uterine inflammation. METHODS: The uterus has two sensory innervations, which are the hypogastric nerve and the pelvic nerve. Since the hypogastric nerve is known to show increased sensitivity to bradykinin, a pain mediator, when the uterus is in inflammatory state, the hypogastric nerve recording was done for electrophysiological study of uterine pain-mediating mechanism in female SD rats (200-250 g). NK1 receptor antagonist (L-703,606) was injected through uterine artery before injecting bradykinin while uterus was under inflammation. RESULTS: The NK-1 receptor antagonist (L-703,606) decreased the spontaneous nerve impulse during inflammation, and it also decreased the hypersensitivity of the hypogastric nerve to bradykinin during the uterine inflammation. CONCLUSION: Substance P mediates the pain sense of hypogastric nerve, and it also plays a role in increased sensitivity of hypogastric nerve to bradykinin while uterus is in inflammatory state.
