Change of Cortisol Level in Rats with Frequent Febrile Seizures
- VernacularTitle:反复热性惊厥大鼠体内皮质醇水平变化
- Author:
fei-xia, ZHENG
;
guang-qian, LI
- Publication Type:Journal Article
- Keywords:
seizures,febrile;
cortisol;
rat
- From:Journal of Applied Clinical Pediatrics
2006;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate cortisol level in experimental frequent febrile seizures model rats.Methods Rats were divided into 3 groups: normal control group(n=10,NC group),hyperthermic control group(n=12,HC group) and febrile seizures group(n=21,FS group).Cortisol level in serum and hippocampus of rats were determined by ELISA.Ultrastructural changes of neurons in hippocampal region CA1 was observed by electron microscop.Results 1.No special ultrastructual findings were observed from neurons in hippocampal CA1 in NC and HC group.In FS group,the neuronal degeneration and edema,the mitochondrial degeneration and edema,the mitochondrion ridge obscured or disappeared.2.Cortisol levels in serum and hippocampus in FS group [(26.57 ? 15.94)?g/L and((4.11)?1.74)?g/L,respectively] were significantly lower than those in HC group [(40.04 ? 15.72)?g/L and(6.70?3.45)?g/L,respectively](P0.05).Positive correlations were demonstrated between serum cortisol level and hippocampus cortisol level(r=0.40 P
