Long-Term Following Up and Curative Effect of Continuous Stosstherapy with Cyclophosphamide in Treatment of Refractory Nephrotic Syndrome in Children in Zhuang Nationality
- VernacularTitle:环磷酰胺连续冲击治疗壮族儿童难治性肾病综合征疗效及远期随访
- Author:
yun-guang, LIU
;
na, LIN
;
qiang, LI
;
yue-yan, HUANG
;
qian, TANG
- Publication Type:Journal Article
- Keywords:
nephrotic syndrome;
cyclophosphamide;
zhuang nationality;
child
- From:Journal of Applied Clinical Pediatrics
2006;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).2.Two days after treatment,total protein(TP) and albumin(Alb) of hemotoplasma were significantly higher than before treatment(all P0.05).3.Toxic side effects: gastrointestinal reaction was seen in 20 cases ((52.63%)),reduction of WBC in 2 cases(5.26%),baldness in 38 cases(100%) and heart impairment in 1 case(2.63%).The sperm test and menstrual onset were normal in 18 cases,whose ages ≥ 8 years at beginning of treatment,who were clinically cured and whose ages ≥17 years at the time of last following up,7 of them who had married could have children.Conclusions Combining CTX(conti-)(nuous) stosstherapy with prednisone standard scheme treated the children in Zhuang nationality with NS,We could got a good curative effect.By using this treatment,not only the plasma TP and Alb level could be increased rapidly and the urine protein could be conversed to negative quickly.The accumulated amount of CTX was less than 80 mg/kg,but the treatment was safety in the recent term, and no impairment of sexual gland was seen at long-term following up.
