Influence of Cyclosporin on C-Reactive Protein, Transforming Growth Factor-?1,Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Rats with Asthma
- VernacularTitle:环孢素对哮喘大鼠C-反应蛋白、转化生长因子-?1、基质金属蛋白酶类及其抑制剂表达的影响
- Author:
zan-cai, SU
;
you, WANG
;
lan-fen, TANG
- Publication Type:Journal Article
- Keywords:
cyclosporin;
asthma;
C-reactive protein;
transforming growth factor-?1;
matrix metalloproteinase;
tissue inhibitor of metalloproteinase
- From:Journal of Applied Clinical Pediatrics
2006;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of cyclosporin on C-reactive protein (CRP),transforming growth factor-?1( TGF- ?1), matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in rats with asthma. Methods Eighty SD rats were randomly divided into normal group, model group, dexamethasone group,low- dose and high-dose of cyclosporin groups. The changes of CRP, TGF-?1, MMPs and TIMPs in samples were measured by computerized image analysis system.Results The contents of CRP, TGF-?1, MMPs and TIMPs in model group were significantly higher than those of control group(all P0.05).Conclusion CRP,TGF-?1,MMPs and TIMPs are related to asthma and certain dose of cyclosporin is similar to hormone.
