Effects of Folate Deficiency during Pregnancy of Rats on Expression of Foliate Binding Proteins Gene and WNT Signal Transduction Pathway in Heart of Offspring
- VernacularTitle:孕鼠叶酸缺乏对子代心脏叶酸结合蛋白1基因及WNT信号转导途径的影响
- Author:
ru, LIU
;
yu-zhu, PENG
;
jing, LI
;
hu, TONG
;
xiao-qi, GU
;
shu-ping, HAN
;
xi-rong, GUO
- Publication Type:Journal Article
- Keywords:
folic acid;
heart;
embryos;
newborn rats;
foliate binding proteins gene 1;
?-catenin gene;
WNT signal transduction pathway
- From:Journal of Applied Clinical Pediatrics
2006;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions of foliate binding protein 1(Folbp1),Wnt and ?-catenin genes on the heart of offspring during the development of embryo,whose mother was deficient of folic acid.Methods Control group involving 18 rats and study group involving 18 rats were choosen from the total 36 adult female SD rats randomly copulate with the male normal rats after feeding different fodder for 2 weeks.The heart of the 13.5,17.5 days embryos and the newborns were obtained.The expressions of Folbp1,Wnt and ?-catenin genes mRNA at the 3 periods were evaluated by RT-PCR.Results The expressions of Folbp1,Wnt and ?-catenin genes mRNA of the study group were significantly weaker than those of the control group in heart of the 13.5,17.5 days embryos and the newborns(all P
