Significance of Chronic Aplastic Anemia in Children by Determining Soluble Stem Cell Factor and Its Receptor
- VernacularTitle:慢性再生障碍性贫血患儿血浆可溶性干细胞因子及其受体水平测定的意义
- Author:
xiao-hui, MENG
;
jun, WANG
;
shu-yun, YUAN
;
jian-fei, FENG
;
hong, WANG
- Publication Type:Journal Article
- Keywords:
anemia,aplastic,chronic;
stem cell factor receptor;
stem cell factor;
function
- From:Journal of Applied Clinical Pediatrics
2006;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the function of soluble stem cell factor receptor(s-kit)and stem cell factor(SCF) in chronic aplastic anemia(CAA).Methods ELISA assay was employed to determine the levels of s-kit and SCF in peripheral blood of CAA patients and umbilical cord blood.Results The levels of s-kit and SCF in peripheral blood of CAA patients are lower than those of normal group and umbilical cord blood group.Conclusions The decreased levels of s-kit and SCF show that s-kit and SCF may play a role in CAA mechanism.The raised levels of s-kit and SCF show that s-kit and SCF may be applied in the field of cord blood transplantation.
