Effect of c-fos Antisense on Neuronal Apoptosis in Rats′ Brain with Pentyleneterazol-Induced Seizure
- VernacularTitle:c-fos反义寡聚核苷酸对癫癎发作后细胞凋亡的影响
- Author:
yue-ying, LIU
;
bao-qiang, YUAN
- Publication Type:Journal Article
- Keywords:
epilepsy;
c-fos;
cell apoptosis;
c-fos antisense
- From:Journal of Applied Clinical Pediatrics
2006;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To probe the effect of c-fos gene on the pentyleneterazol-induced hippocampal neurons apoptosis.Methods Using immunohistochemistry,TUNEL and flow cytometry(FCM),we detected the Fos expression and the apoptosis of hippocampal neurons;we injected c-fos antisense into ventrile before epilepsy and detected as up.Results Epilepsy can induce the expression of Fos in the hippocampus and peaking at 1 h(P
