Changes of Plasma Brain Natriuretic Peptide Concentration Induced Therapy by Daunorubicin and Its Clinical Significance in Children with Acute Leukemia
- VernacularTitle:柔红霉素诱导治疗急性白血病患儿前后血浆脑钠素变化的意义
- Author:
cong-jun, WANG
;
xiao-qing, ZHENG
;
hong-bao, FEI
- Publication Type:Journal Article
- Keywords:
daunorubicin;
cardiotoxicity;
brain natriuretic peptide;
acute leukemia;
child
- From:Journal of Applied Clinical Pediatrics
2006;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of the brain natriuretic peptide(BNP) in evaluating the cardiotoxicity caused by daunorubicin(DNR) through studying the changes of the plasma BNP levels in children with acute leukemia who accepted the chemotherapy with DNR.Methods Thirty-one children with acute lymphoblastic leukemia(ALL) admitted in the year of 2002-2004 underwent the chemotherapy in DVLP project.The plasma level of BNP was measured by enzyme linked immunosorbent assay(ELISA) and the left ventricular end diastolic diameter(LVEDD) by color Doppler respectively before and after the administration of DNR.Simultaneously,electrocardiography(ECG) and cardiac muscle enzymes(LDH1,CK-MB) were measured as routine.Results The plasma level of BNP increased from(3.97?2.41) ng/L to(18.25?7.63) ng/L(P
