Influence of Taurine Supplementation on Ultrastructure of Islet ? Cells in Neonatal Rats with Low Birth Weight
- VernacularTitle:牛磺酸对低出生体质量仔鼠胰岛?细胞超微结构的影响
- Author:
ke, YUAN
;
zong-de, XIE
;
jin-tao, HU
;
wen, LI
- Publication Type:Journal Article
- Keywords:
low birth weight;
? cell;
ultrastructure;
taurine
- From:Journal of Applied Clinical Pediatrics
2006;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of taurine supplementation during early postnatal life on body weight and ultrastructure of islet ? cells in neonatal rats with low birth weight(LBW).Methods LBW neonatal rats were made by feeding 20%(C group) or 10%(R group) protein diet to fetal rats during gestation and lactation.Half of femal rats in group R were given a supplementation with 2.5% taurine drinking water(RT group) only during lactation,while other femal rats freely drunk.At postnatal day 1 and 21,the neonatal rats were weighted and their pancreas were removed.The ultrastructural changes of ? cells were observed by electron microscopy.Results At postnatal 21 days,the body weight of offsprings in group RT was significantly highter than that in group R(P=0.003);and the ultrastructure of ? cells in group RT got more improvement than that in group R.Conclusion Taurine supplementation can improve the growth-catch-up and the ultrastructure of islet ? cells of neonateal rats with LBW.
