Changes of Serum Complement 3 and Complement 4 in Neonates with Hypoxic-Ischemic Encephalopathy and Its Clinical Significance
- VernacularTitle:缺氧缺血性脑病新生儿血清补体3、4水平变化的意义
- Author:
jun, WANG
;
shao-mei, ZHANG
- Publication Type:Journal Article
- Keywords:
infant,newborn;
hypoxic-ischemic,brain;
complement 3;
complement 4
- From:Journal of Applied Clinical Pediatrics
2006;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the changes of serum complement 3(C_3) and C_4 in neonates with hypoxic-ischemic encephalopathy(HIE) and its effects on non-specific immunological function.Methods Sixty-seven neonates with HIE and 30 normal full-term infants were recruited in the study.According to characteristic of immunological function and severity of HIE,the neonates were divided into 1-3 day group(n=32)and 4-6 day group(n=35).In each group,it was divided into mild group and moderate-severe group.The complement in serum was detected by radial immunodiffusion assay with Behring Nephelometer 100 Analyzer.Results In 1-3 day group,levels of C_3,C_4 in serum were lower than those in control group(P
