Correlative Analysis on Human Leukocyte Antigen-DQ Gene Susceptibility for Autoimmune Polyglandular Syndrome,Type 1 Diabetic Mellitus and Autoimmune Thyroid Disease
- VernacularTitle:自身免疫多腺体综合征Ⅲ型、1型糖尿病及自身免疫性甲状腺疾病与人类白细胞抗原-DQ基因的相关性
- Author:
di, WU
;
cheng, ZHU
;
chun-xiu, GONG
;
yan-mei, SANG
- Publication Type:Journal Article
- Keywords:
polyendocrinopathies,autoimmune;
diabetic mellitus,insulin-dependent;
thyroiditis autoimmune;
human leukocyte antigen;
polymerase chain reaction
- From:Journal of Applied Clinical Pediatrics
2006;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the associations of human leukocyte antigen(HLA)-DQ gene with autoimmune polyglandular syndrome(APS),type 1 diabetic mellitus(T1DM) and autoimmune thyroid disease(AITD).Methods Fifteen cases of APS,29 cases of T1DM and 40 cases of AITD were selected as research subjects,while 27 healthy children were selected as controls.The DQA1 and DQB1 alleles were determined by polymerase chain reaction(PCR) and sequence-based typing method.The difference of their frequency in children and adolescents was analyzed.Results Compared with controls,APS and T1DM patients had increased frequency of subjects with DQA1*0301,0501(all P
