Relationship between Apolipoprotein E Gene Polymorphism and Disturbance of Serum Lipid Metabolism in Children with Primary Nephrotic Syndrome
- VernacularTitle:载脂蛋白E基因多态性与原发性肾病综合征脂质代谢紊乱的关系
- Author:
yuan-han, QIN
;
peng, HU
;
ming-fang, LI
;
wei-xiong, LIN
- Publication Type:Journal Article
- Keywords:
nephrotic syndrome;
apolipoprotein;
polymorphism;
child
- From:Journal of Applied Clinical Pediatrics
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the distribution of apolipoprotein E(apoE) genotypes and alleles in children with primary nephrotic syndrome(PNS),and to investigate the relationship between apoE gene polymorphism and disturbance of serum lipid metabolism.Methods Forty-six children with PNS were compared with 39 age-sex-matched healthy children.Serum levels of total cholesterol(TC),triglyeride(TG),high density lipoprotein-cholesterol(HDL-C),low density lipoprotein-cholesterol(LDL-C),apoA_1,apoB and apoA_1/B were detected,and polychain reaction single-strand conformation polymorphism(PCR-SSCP) combined with gene sequence determination was used to confirm the apoE genotypes in two groups.Results 1.Serum TC,TG,HDL-C,LDL-C,apoB and apoA_1/B in PNS group were higher than those of control group,respectively(P
