Diagnostic Value of Neuron-Specific Enolase in Children with Meningitis
- VernacularTitle:神经元特异性烯醇化酶对脑膜炎患儿的诊断价值
- Author:
xiu-fang, ZHANG
;
zhao-hui, SUN
;
ruo-peng, SUN
- Publication Type:Journal Article
- Keywords:
neuron-specific enolase;
meningitis;
cerebrospinal fluid
- From:Journal of Applied Clinical Pediatrics
2004;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of neuron-specific enolase(NSE) in cerebrospinal fluid(CSF) in children with meningitis.Methods NSE levels in CSF of 18 children with purulent meningitis,13 children with tuberculous meningitis and 25 children with viral meningitis were determined by enzyme-linked immunosorbent assay(ELISA).Results CSF-NSE levels increased significantly in children with purulent meningitis and tuberculous meningitis compared with that of control group(P0.05);CSF-NSE levels increased significantly in children with purulent meningitis and tuberculous meningitis,compared with that of viral meningitis group(P0.05).Conclusions The determination of the neuron-specific enolase in cerebrospinal fluid can be used as an important parameter for identifying bacterial meningitis from viral meningitis.It also can be used to estimate the severity and prognosis of meningitis in children.
