Effect of Valproate on Leptin and Serum Lipids in Children with Epilepsy
- VernacularTitle:丙戊酸钠对癫患儿瘦素及血脂的影响
- Author:
zhao-chun, WEN
;
ru-ming, WANG
- Publication Type:Journal Article
- Keywords:
epilepsy;
valproate;
leptin;
serum lipid
- From:Journal of Applied Clinical Pediatrics
2004;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of valproate(VPA) on body mass index(BMI),leptin and serum lipids in children with epilepsy.Methods (Twenty-)four cases with epilepsy were selected.BMI and serum levels of leptin,total cholesterol(TC),(triacylgly)-cerol(TG),high density lipoprotein-cholesterin(HDL-C),low density hipoprotein-cholesterin(LDL-C) after treated with VPA for 3 months and 6 months were determined.Results The levels of BMI,leptin,TC,TG,LDL-C after treated 3 months were all significantly higher than those of initial(all P0.05).Those in treated 6 months were same as levels of treated 3 months.Only LDL-C level was lower than that of 3 months and same as level of before treatment.Conclusion VPA do have efficacy to cause obesity in children with epilepsy,and most of the cases occur in the first 3 months after VPA treatment.
