Expression of Death Receptor 4 and Death Receptor 5 in Human Craniopharyngioma
- VernacularTitle:死亡受体4和5在颅咽管瘤中的表达
- Author:
pei-dong, LI
;
zhong-wei, ZHAO
;
xin-jun, WANG
;
dong-ling, GAO
;
yun-han, ZHANG
- Publication Type:Journal Article
- Keywords:
craniopharyngioma;
apoptosis;
tumor necrosis factor-related apoptosis-inducing ligand;
death receptor
- From:Journal of Applied Clinical Pediatrics
2004;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of death receptor 4(DR4) and DR5 in human craniopharyngioma.Methods The expression of DR4 and DR5 was determined by immunohistochemistry and in situ hybridization in 28 samples of craniopharyngioma and 25 samples of normal brain tissue.Results With low expression in partial normal brain tissue,DR was expressed highly in all of the craniopharyngioma samples.High DR expression in craniopharyngioma tissue differed from low DR expression in normal brain tissue(P0.05).Conclusions High DR expression is prevalent in craniopharyngioma tissue.This may contribute to the apoptosis-induced therapy of craniopharyngioma.The control of DR expression lays in protein level.This may contribute to the selective induced-apoptosis of tumor necrosis factor-related apoptosis-induced ligand.
