Expression of Apoptosis Associated Proteins Survivin and Fas in Nephroblastoma and Their Clinical Significance
- VernacularTitle:凋亡相关蛋白Survivin、Fas在肾母细胞瘤中的表达及其临床意义
- Author:
zhong, JIANG
;
chuan-min, YANG
;
bu-xian, JIANG
- Publication Type:Journal Article
- Keywords:
nephroblastoma;
immunohistochemistry;
Survivin;
Fas;
child
- From:Journal of Applied Clinical Pediatrics
2004;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of Survivin and Fas in the tumor cells′ invasion and metastasis and to evaluate whether they can be used as a reliable predictor for diagnosis and a new treatment pattern for therapy.Methods Thirty paraffin-embeded material of nephroblastoma were collected.The control group was composed of 15 specimens of normal kidney tissue acquired from paratumor region of the material.Immunohistochemistry methods was used to detect the stain of Survivin and Fas proteins in normal kidney and nephroblastoma specimens,compared them with clinical stage,pathology type and the outcome.Results Positive expression rate of Survivin in tumor specimens and significantly higher than that in control group(53.3% vs 0,P
