Changes of Amplitude of Ion Channels Currents in Developing Hippocampal Neurons
- VernacularTitle:发育中的海马神经元离子通道功能变化
- Author:
zhen-biao, LI
;
xi-ru, WU
;
yu-wu, JIANG
- Publication Type:Journal Article
- Keywords:
patch-clamp techniques;
hippocampus;
neurons;
development;
ion channels
- From:Journal of Applied Clinical Pediatrics
2004;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of the amplitude of ion channels currents in developing hippocampal neurons.Methods Using whole-cell patch-clamp techniques in cultured hippocampal neurons whose cultured day were 6 d and 16 d,respectively,changes of the amplitude of ion channels currents in developing hippocampal neurons were explored.Results Compared with the hippocampal neuron whose cultured day was 6 d,there were no statistical differences of the amplitude of voltage dependent sodium currents of hippocampal neuron whose cultured day was 16 d.The amplitude of voltage dependent potassium currents of hippocampal neuron whose cultured day was 16 d were significantly increased(P
