Study on Immuniated Fnnction in Infants with Bronchiolitis
- VernacularTitle:毛细支气管炎患儿免疫功能状态评价的意义
- Author:
ya-li, LIU
;
xi-qiang, YANG
- Publication Type:Journal Article
- Keywords:
bronchiolitis;
cytokine;
THl cell;
TH2 cell
- From:Journal of Applied Clinical Pediatrics
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the immuniated function of infants with bronchiolitis. Methods In vitro production of IL-18,12, 10, 4, IFN-? by peripheral blood mononuclear cells (PBMC) and plasma IgE of bronchiolitis infants measured by enzyme-linked im-munosorbent assay, expression of lymphocyte activation gene - 3 (LAG - 3) mRNA from PBMC measured by semi - quantitative RT- PCR.Forteen healthy children were as normal control. Results Compared with normal control, IL - 12 (390. 94 ? 95. 88 vs 452.44?195.07) ng/L and IL-18(146.23? 55. 81 vs 246.69?121.29) ng/L activity were significantly decreased (P0.05) ;The levels of IL-4(30. 52 ? 17. 65 vs 16.20? 8.94) ng/L and IL-10 (302. 40 ? 100.04 vs 195.30? 84.01) ng/L were elevated significantly(P
