Changes of Drug Transporters Expression in Brains of Chronic Epileptic Rats Induced by Lithium-Pilocarpine
- VernacularTitle:毛果芸香碱致慢性癫大鼠脑内药物转运体表达的变化
- Author:
yi, GUO
;
li, JIANG
- Publication Type:Journal Article
- Keywords:
organic anion transporters;
P-glycoproteins;
epilepsy,spontaneous recurrent seizures;
pilocarpine
- From:Journal of Applied Clinical Pediatrics
2004;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of drug transporter organic anion transporting polypeptide2(Oatp2) and P-glycoprotein(P-gp) in brains of chronic epileptic rats induced by lithium-pilocarpine.Methods Chronic epilepsy modles were elicited after status epilepticus(SE) induced by lithium-pilocarpine in adult Wistar rats.The expressions of Oatp2 and P-gp were detected by immuno-histochemistry(SABC) method.Results Positive expression of Oatp2 was predominantly in the plexus epithelial cells and(blood-brain) barrier endothelial cells.Weak staining for Oatp2 was also detected in the neurocyte.In contrast,apparent expression of(P-gp) was seen in brain capillary and neurocyte only.Compared with normal control rats,expression of Oatp2 on the plexus epithelial cells and brain capillary in chronic epileptic rats was significantly decreased(P
