Relationship between Tumor Necrosis Factor-? and Interferon-? Polymorphism with Infant Cytomegalovirus Hepatitis
- VernacularTitle:肿瘤坏死因子-?和干扰素-?多态性与婴儿巨细胞病毒肝炎的关系
- Author:
xiao-hong, WANG
;
hong-mei, GUO
;
qi-rong, ZHU
- Publication Type:Journal Article
- Keywords:
cytomegalovirus hepatitis;
interferon-?+874;
tumor necrosis factor-?+238;
tumor necrosis factor-?+308;
single nucleotide polymorphism
- From:Journal of Applied Clinical Pediatrics
2004;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between tumor necrosis factor(TNF)-? promoter G238A,G308A and interferon(IFN)-?+874A/T polymorphism and susceptibility to cytomegalovirus(CMV) hepatitis.Methods A TaqMan fluorescence polymerase chain reaction(PCR) in the IFN-?+874A/T and TNF-? gene promoter region single nucleotide polymorphism was tested in the subjects,including 87 infants with CMV hepatitis and 89 children without CMV hepatitis.Results No evident difference of TNF-? +238G/A and+308G/A allele frequency was found between infants with CMV hepatitis and controls.The cases of IFN-?+874 AA,AT and TT genotype were 64,20,3 cases in the infant CMV hepatitis group,and 45,26 and 18 cases in the control group,respectively.There was significant difference in IFN-?+874 allele genotype and frequency between infants with CMV hepatitis and the control group(P=0.001,P
