Effect of Topiramate on Pentetazole-Induced Epileptic Rats Weight Changes and Serum Level of Leptin,Expression of Neuropepiticle Y in Arcuate Nucleus
- VernacularTitle:托吡酯对戊四氮致癫大鼠体质量及血清瘦素和弓状核神经肽Y表达的影响
- Author:
hong-yan, WEI
;
yan-hua, QIU
;
hai-yan, WANG
;
ke-yi, ZHAN
- Publication Type:Journal Article
- Keywords:
topiramate;
leptin;
body weight;
epilepsy;
neuropeptide Y;
rat
- From:Journal of Applied Clinical Pediatrics
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of topiramate(TPM) on serum level of leptin and the expression of neuropeptide Y(NPY) in arcuate nucleus and their relationship with weight changes in pentetruzole-induced epileptic rats,and to explore the mechanism that TPM could reduce the weight.Methods One hundred and fifteen Wistar rats were randomly divided into 4 groups:blank control group,TPM contrast group,pentylenetetrazol(PTZ) model group,and TPM group.Weight changes were measured every 3 days.Serum leptin level was detected with rodioimmunity method and hypothalamic arcuate nucleus NPY expression was measured by immunohistochemical ABC technique at the 2~(nd),4~(th),6~(th) weekend,respectively.Results In TPM control group and TPM group weight loss appeared in the 4~(th) week compared with other groups at the 3~(rd) weekend and fell to the lowest at 4~(th) weekend(P
