Expression and Clinical Significance of Cyclin Kinase Inhibitor P21~(WAF1) and P27~(KIP1) in Children with Acute Leukemia
- VernacularTitle:细胞周期蛋白依赖激酶抑制因子P21~(WAF1)、P27~(KIP1)在急性白血病的表达及其意义
- Author:
yong-chun, SU
;
you-hua, XU
;
jie, YU
;
xiao-mei, LIU
- Publication Type:Journal Article
- Keywords:
acute leukemia;
cyclin;
inhibitor;
cell cycle;
children
- From:Journal of Applied Clinical Pediatrics
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of cyclin kinase inhibitor P21~(WAF1) and P27~(KIP1)in children with acute leukemia and its clinical significance.Methods A total of 32 hospitalized children with acute leukemia(AL) were included in this study.Their bone marrow samples were collected before chemotherapy and individual patient was detected after complete remission(CR).The method of immunocytochemistry was used to estimate the expression of P21~(WAF1) and P27~(KIP1).Both positive percentage and intensity of the cells were counted.Results Findings showed that the positive ratios of P21~(WAF1) and P27~(KIP1) in total samples,ALL samples and AML samples were lower than the control group(P
