Effect and Significance of Dexamethasone on Expression of Nuclear Transcription Factor-?B in Childhood Acute Lymphoblastic Leukemia
- VernacularTitle:地塞米松对急性淋巴细胞白血病患儿核转录因子-?B表达的影响及意义
- Author:
wei, XU
;
qi, AN
;
tian-yang, XUE
;
ji-zhao, GAO
- Publication Type:Journal Article
- Keywords:
nuclear factor kappa B;
leukemia,lymphocytic,acute;
immunohistochemistry
- From:Journal of Applied Clinical Pediatrics
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of nuclear transcription factor-?B(NF-?B) in childhood acute lymphoblastic leukemia(ALL) and the effect of dexamethasone(DEX) on its expression,to provide the experimental base for corresponding clinical treatment of the ALL,in which NF-?B is taken as a target.Methods 1.The biotin-streptavidin method was used to detect NF-?B P65 protein on 20 childhood ALL patients and 20 healthy children.2.The effect of DEX at clinically relevant dosage on NF-?B P65 protein were also detected by the biotin-streptavidin method.Results 1.The positive expression rate of NF-?B P65 protein in childhood ALL patients was 85.50%,obviously higher than that in normal group(10.0%)(?~2=22.56 P
