Observation of Clinical Side Effects of High-Dose-Methotrexate in Treating Children with Acute Lymphoblastic Leukemia
- VernacularTitle:大剂量甲氨蝶呤治疗急性淋巴细胞白血病的不良反应
- Author:
ying, LIU
;
wu-qing, WAN
;
bing, DENG
- Publication Type:Journal Article
- Keywords:
high dose-methotrexate;
acute lymphoblastic leukemia;
side effects
- From:Journal of Applied Clinical Pediatrics
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
1.0 mmol/L).The clinical side effects after medication circa were compared between two groups.Results There was no significant difference in myelosuppression,liver functional lesion,gastrointestinal tract reaction and infection in 2 groups.But following the increase of MTX blood drug level,the incidence rate of skin mucosa contamination,electrocardiographic abnormality,the cardiac creatase abnormity and nervous system symptoms significantly increased.Conclusions In the course of child ALL treatment with HD-MTX+CF,the side effects are common and individual difference is obvious.Specific treatment on individuals is suggested.J Appl Clin Pediatr,2006,21(3):170-171
