Expression of mdm2 Genes in Nephroblastoma in Childhood and Its Relationship with Clinical Pathological Parameters
- VernacularTitle:mdm2基因在肾母细胞瘤中的表达及其与临床病理因素的关系
- Author:
hua, WEI
;
yan, KONG
;
zhen-huai, JIN
;
shu-min, CHEN
;
yong, DING
- Publication Type:Journal Article
- Keywords:
mdm2;
nephroblastoma;
children;
immunohistochemistry
- From:Journal of Applied Clinical Pediatrics
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of mdm2 genes in nephroblastoma in children and relationship between mdm2 gene and clinical pathological parameters.Methods The protein expressions of mdm2 in 24 cases of nephroblastoma were detected with S-P immunohistochemical method.The relationships between mdm2 expression and clinicopathological parameters were analyzed.Results The positive rates of mdm2 in 24 cases of nephroblastoma were correlated with lymph node metastasis,clinical stage and tumor differentiation.There was a positive relationship between mdm2 protein expression and clinicopathological parameters such as lymph node metastasis,clinical stage and degree of differentiation(P
