Effects of Dexamethasone on Changes of CD4~+,CD8~+ Lymphocyte in Children with Viral Encephalitis
- VernacularTitle:地塞米松对病毒性脑炎患儿CD4~+、CD8~+淋巴细胞水平的影响
- Author:
yu-miao, ZHANG
;
rong, YANG
;
fang-jun, LUO
;
yi, ZHOU
- Publication Type:Journal Article
- Keywords:
viral encephalitis;
dexamethasone;
children;
T lymphocyte subsets
- From:Journal of Applied Clinical Pediatrics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of dexamethasone (DEX) therapy on the clinical outcome and changes of lymphocyte subsets in children with mild and severe encephalitis.Methods Eighty-two children with mild and severe viral encephalitis were randomly divided into two groups: with DEX treatment (n=46) or without(n=36).The clinical efficacy was evaluated 3 weeks later, and the clinical manifestation were also observed. The changes of CD4~+,CD8~+ T lymphocyte percentage were determined by flow cytometry on admission and at 1 week,4 weeks after treatment.Another group of 20 cases was enrolled as control group.Results Compared with the control group,both the DEX treatment group and non-DEX treatment group showed a reduced CD4~+ lymphocyte count, an increased CD8~+ lymphocyte count(P
