Expression of c-Fos Protein and Character of Mossy Fiber Sprouting in Hippocampus of Rat with Febrile Seizures
- VernacularTitle:热性惊厥大鼠海马区c-Fos蛋白表达及苔藓纤维发芽特征
- Author:
jian-ping, ZHOU
;
fan, WANG
;
rui-lin, LI
;
shao-ping, HUANG
;
ya-le, GUO
- Publication Type:Journal Article
- Keywords:
seizures,febrile;
c-Fos protein;
mossy fiber sprouting;
hippocampus
- From:Journal of Applied Clinical Pediatrics
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of c-Fos protein and character of mossy fiber sprouting(MFS) in hippocampus of rat with febrile seizures(FS).Methods Thirty-six 21-day-old male Sprague-Dawley rats were randomly divided into FS group,febrile control(FG) group and normal control(NG) group.FS was established by hyperthermal bath.Immune histochemistry and(Timm′s) staining were used to examine the expression of c-Fos protein in CA1 region and MFS in CA3 region of hippocampus.Results Excessive expression of c-Fos protein presented in the hippocampal CA1 region of FS group.The surface area percentage of c-Fos protein of FS group[(2.26?0.23)%] was higher than that of FG group[(1.08?0.19)%] and NG group[(0.71?0.14)%],there were significant difference between FS group and the other two groups(?~2=10.48 P
