Influence of Recombinant Human Epythropoietin on Nitric Oxide in the Brain and Endothelin in the Blood of Newborn Rats after Cerebral Hypoxia-Ischemia
- VernacularTitle:促红细胞生成素对缺氧缺血新生鼠脑匀浆一氧化氮及血浆内皮素的影响
- Author:
yan, LIN
;
ling, WANG
- Publication Type:Journal Article
- Keywords:
rherythropoietin;
nitric oxide;
nitric oxide synthase;
endothelin;
cerebral hypoxia;
cerebral ischemia;
neonatal rat
- From:Journal of Applied Clinical Pediatrics
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of recombinant human erythropoietin(rhEPO) injection about nitric oxide(NO) and nitric oxide synthase(NOS) level in the brain and endothelin(ET) level in the blood after hypoxia-ischemia brain damage(HIBD) in neonatal rats,and elucidate the possible mechanism of the neuroprotective effect of rhEPO administered to the rat pup prior to cerebral hypoxia-ischemia.Methods Seven days-old SD rats were divided into control group,hypoxia-ischemia group(HI) and EPO group.NO activity,NOS level in the brain and ET in the blood were determined at 6 h after hypoxia-ischemia.Results NO and NOS levels in the brain and ET level in the blood were increased after HIBD in neonatal rats(P
