Expression and Regulation of Cardiotrophin-1 in Ischemia1 Reinfusion Cardiac Muscle of Rats and Effect of Neuregwlin-1
- VernacularTitle:心肌营养素-1在大鼠缺血再灌注心肌中的表达及神经调节蛋白-1对其表达的促进作用
- Author:
hui, CHEN
;
chao, LU
;
xiao-song, SHAO
;
yan, ZHOU
;
sheng-hua, WU
;
xiang-qing, KONG
- Publication Type:Journal Article
- Keywords:
cardiotrophin-1;
ischemia;
reinfusion;
neuregulin-1;
rat
- From:Journal of Applied Clinical Pediatrics
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression of cardiotrophin-1(CT-1) in ischemia-reinfusion cardiac muscle of rats and the effect of neuregulin-1(NRG-1).Methods The model of ischemia-reinfusion cardiac muscle of rats were prepared,35 rats were randomly divided into 4 groups:model group(n=8),NRG-1 pretreatment group(n=9),pseudo-surgery group(n=8) and normal control group(n=10).The CT-1 mRNA in the observed cardiac muscle of all groups was measured by RT-PCR and the relative amount of CT-1 mRNA were calculated,and for statistical treatment.Results The CT-1 mRNA of model group was(63.96?9.34),and it was higher than that of pseudo-surgery group(36.16?5.43)and normal control group(36.84?4.64).The significant differences were found in 3 groups(F=47.37 P
