Expression of Telomeric Associated Protein in Human Fetal Cadiacmyocytes
- VernacularTitle:胎儿心肌细胞端粒相关蛋白的表达
- Author:
guang-mou, ZHANG
;
xian-wei, WANG
;
chang-qin, JING
;
zhi-kun, GUO
;
peng, WANG
- Publication Type:Journal Article
- Keywords:
telomerase reverse transcriptase;
telomerase-associated protein;
telomeric repeat binding factor 2;
myocardium
- From:Journal of Applied Clinical Pediatrics
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate protein expression of telomerase reverse transcriptase(TERT),telomerase-associated protein 1(TP1) and telomeric repeat binding factor 2(TRF2) in human fetal cadiacmyocytes.Methods Using immunohistochemical method,sections of human fetal hearts were stained with antibodies against TERT,TP1 and TRF2.Results Expression of TERT was gradually decreased with development in human fetal cadiacmyocytes nuclear.Expression of TP1 and TRF2 was gradually increased with development in human fetal cadiacmyocytes cytoplasm.Conclusion Down-regulation of TERT and up-regulation of TP1 and TRF2 may promote the permanent withdrawal of cardiomyocytes from the cell cycle and enter terminal differentiation and myocardium hypertrophy.
