Influence of Pulmonary Hypertension Induced by Left-to-Right Shunt on Pulmonary Collagen Remodeling
- VernacularTitle:左向右分流致肺动脉高压对大鼠肺动脉胶原代谢的影响
- Author:
zhen-hui, HAN
;
xi, ZHANG
;
zhen-yu, XIONG
;
yong, GAI
- Publication Type:Journal Article
- Keywords:
pulmonary hypertension;
left-to-right shunt;
rat;
collagen
- From:Journal of Applied Clinical Pediatrics
2004;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a rat model of pulmonary hypertension induced by left-to-right shunt and explore the influence of high pulmonary blood flow on pulmonary vascular collagen remodeling.Methods Abdominal aorta and inferior vena cava shunting was produced in rats. Pulmonary artery meanpressure (PAMP) of each rat was measured by using a right cardiac catheterization.Pulmonary artery collagen Ⅰ and Ⅲ were detected using immunohistochemisty.Results After 11 weeks of shunting the Qp/Qs was 3.3∶1.0,indicating a large shunt. Pulmonary artery mean pressure was increased as compared with controls[(23.0?0.9) mm Hg vs (15.7? 1.1) mm Hg,P
