Changes and Relationship of Serum Insulin-Like Growth Factor-1 and Leptin in Children with Growth Hormone Deficiency
- VernacularTitle:生长激素缺乏儿童血清胰岛素样生长因子-1和瘦素水平的变化及其相互关系
- Author:
xiao-li, ZHANG
;
jun-hua, DONG
- Publication Type:Journal Article
- Keywords:
growth hormone deficiency;
insulin-like growth factor-1;
leptin
- From:Journal of Applied Clinical Pediatrics
2004;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes and relationship of serum insulin-like growth factor-1(IGF-1) and leptin in children with growth hormone deficiency(GHD).Method Serum IGF-1 and leptin levels were measured by immunoradiometric assay in 20 prepuberal normal children and 23 children with GHD.Results Serum IGF-1 level in GHD group(51.158?29.988)?g/L was significantly lower than that in controls(112.680?41.540)?g/L.Serum leptin levels in GHD group(6.002?2.204)?g/L was significantly higher than that in controls(4.523?2.204)?g/L.There was no significant correlation between serum IGF-1 and leptin.Conclusion IGF-1 and leptin regulate growth in children with GHD in their individual way.
