Clinical Significance of Serum Soluble Vascular Cell Adhesion Molecular - 1 and Immunoglobulin Anti - Endothelial Cells Antibodies in Children with Henoch - Schonlein Purpura
- VernacularTitle:过敏性紫癜患儿可溶性血管细胞黏附分子-1、免疫球蛋白A抗内皮细胞抗体检测的意义
- Author:
san-ping, WANG
;
jian-jun, WANG
;
hai-jin, XIONG
;
yi-fan, SU
;
hong, CHEN
- Publication Type:Journal Article
- Keywords:
Henoch - Schonlein purpura;
vascular cell adhesion molecule - 1;
immunoglobulin A
- From:Journal of Applied Clinical Pediatrics
2004;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore clinical significence of soluble vascular cell adhesion molecular(SVCAM - 1),immunoglobulin A (IgA) anti- endothelial cells antibodies(AECA) in Henoch-Schonlein purpura(HSP) and their relationships. Methods SVCAM-1 were detected by ELISA between 55 cases with HSP (40 cases in acute stage and 15 cases in recovery) and 20 controls. Results The levels of serum SVCAM - 1 of the HSPN cases were significantly increased compared with the other HSP. In addition, the serum level of SVCAM - 1 in acute stage HSP children was significantly higher than that in recovery stage and normal controls. IgA AECA positive rate in HSPN was higher than that of without nephritis group. The level of serum SVCAM - 1 in IgA AECA positive children was higher than that of IgA AECA negative children. Conclusion SVCAM - 1 and IgA AECA may participate in the pathogegesis of HSP, and the level of molecule is correlated with the progress of HSP.
