Expression of Vascular Endothelial Growth Factor- C Related Metastasis in Solid Tumors of Children
- VernacularTitle:血管内皮生长因子-C在儿童实体肿瘤生长转移中的表达
- Author:
min, XU
;
qi-min, CHEN
;
min-zhi, YIN
;
wen-zhu, ZHANG
- Publication Type:Journal Article
- Keywords:
vascular endothelial growth factor -c;
neuroblastoma;
willms' tumors
- From:Journal of Applied Clinical Pediatrics
2004;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluated the expression of vascular endothelial growth factor -C(VEGF-C) in children with neurob-lastomaor willms' tumors. Methods The specimens from 33 cases with neuroblastoma and 30 cases with willms' tumors were detected by immunohistochemical staining method. Results In thirty - three cases of neuroblastoma, stage III VEGF - C positive rate were 37.5% (3/8),stage IV were 32% (8/25);favourable histological(FH) were 45%(9/20),unfavourable favourable histological(UFH) were 30.8%(4/13).Cases with distant meta stasis were 32% (8/25),and cases with lymph node involvement were 66.7%(4/6). In 30 cases with willms' tumors,stage I + II were 26.7% (4/15),while stage III + IV were 40% (6/15), FH were 27.3% (6/22), while UFH were 25% (2/8). Cases with distant metastasis were 33.3% (4/12),and cases with lymph node involvement were 60% (3/5). VEGF-C positive expression rate was significantly higher in tumors from children with lymph node metastasis than those without. Conclusion The study shows that expression of VEGF -C is related to lymph node metastasis.
