Influence of Inhaled Glucocorticoids on Nuclear Factor - KB and Th2 Cytokines of Murine with Asthma
- VernacularTitle:吸入性糖皮质激素对哮喘小鼠核因子-?B及Th2类细胞因子的影响
- Author:
chun-yan, KONG
;
yan, ZHANG
;
ming-yue, WANG
;
min, WANG
;
yan-ping, LIU
;
ping, ZHANG
- Publication Type:Journal Article
- Keywords:
glucocorticoids;
nuclear factor-?B;
asthma;
interleukin;
murine
- From:Journal of Applied Clinical Pediatrics
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of glucocorticoids on nuclear factor - ?B expression and Th2 cytokines and the relationship of these two factors. Methods Thirty BALB/c mice were divided randomly into normal control groups, asthmatic groups and budesonide inhalation group. The expression of NF - ?B was observed by immunocytochmical staining; IL - 4, IL - 5, IFN - ? proteins in HALF were measured by ELISA. Results The percentage of cells of active NF - ?B, IL - 4 and IL - 5 protein in BALF of asthmatic group was significantly higher than that of control group, which was significantly reduced by budesonide(P
