Changes of Tumor Necrosis Factor - a and Souble Intercellular Adhesion Molecule - 1 in Serum and Cere-brospinal Fluid of Children with Viral Encephalitis
- VernacularTitle:病毒性脑炎患儿血清和脑脊液肿瘤坏死因子-?和可溶性细胞间黏附分子-1的变化
- Author:
yue-qing, BU
;
sheng-ying, DONG
- Publication Type:Journal Article
- Keywords:
viral encephalitis;
children;
tumor necrosis factor- ?;
souble intercellular adhesion molecule- 1
- From:Journal of Applied Clinical Pediatrics
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of tumor necrosis factor- ?(TNF- ?) and souble intercellular adhesion molecule - 1 (sICAM - 1) in serum and cerebrospinal fluid (CSF) in children with viral encephalitis (VE) before and after treatment,and to explore the pathogenesis of the cytokins in VE. Methods The levels of TNF - ? and sICAM - 1 in serum and CSF were determined before and after treatment using EL1SA in 38 children who were admitted with VE, and 20 children as normal controls. Results The levels of TNF- ? and sICAM - 1 in serum and CSF before treatment were obviously higher than those of control group,and the difference was significant(P 0. 05), but the serum and CSF TNF - ? and sICAM - 1 levels in SVE group were higher than those of control group(P
