Changes of Transforming Growth Factor-?_1 Levels in Children with Immunoglobulin A Glomerulonephritis and Mesangial Proliferate Glomerulonephrit is
- VernacularTitle:IgA肾炎和系膜增生性肾小球肾炎患儿血和尿液转化生长因子-?_1的变化
- Author:
min-shu, ZOU
;
jian, YU
;
wei-xun, HE
;
guang-hua, ZHU
- Publication Type:Journal Article
- Keywords:
transforming growth factor-beta;
immulogin A glomerulonephritis;
mesangial proliferate glomerulonephritis
- From:Journal of Applied Clinical Pediatrics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the levels of transforming growth factor-?_1(TGF-?_1) in plasma,serum and urinary of children with Immunoglobulin A glomerulonephritis(IgAGN) and mesangial proliferate glomerulonephritis(MsPGN) and explore the different effects of TGF-?_1 in the two diseases.Methods The plasma,serum and urinary TGF-?_1 levels were measured in 24 children with IgAGN,and 30 children with MsPGN and 30 healthy controls by enzyme-linked immunosorbent assay(ELISA).Results The TGF-?_1 levels in plasma,serum and urinary samples of IgAGN group were increased.The TGF-?_1 levels of IgAGN were significantly higher than those of MsPGN and heathy controls(P(0.05)).Conclusion It is showed that TGF-?_1 plays a diffenent role in IgAGN and MsPGN.
