Bailing Capsule in Preventing Epithelial -Mesenchymal Transitionin Rats with Tubulointerstitial Fibrosis
- VernacularTitle:百令胶囊对肾小管间质纤维化大鼠肾小管上皮-间质转分化的干预作用(英文)
- Author:
de-an, ZHAO
;
da-sheng, YANG
;
ling-yun, BI
;
hui-qin, XU
;
ying, ZHAO
;
xin-de, CHEN
- Publication Type:Journal Article
- Keywords:
cordyceps sinensis;
tubulointerstitial fibrosis;
epithelial -mesenchymal transition;
adenine
- From:Journal of Applied Clinical Pediatrics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explorethe effect of Bailingcapsule on epithelial-mesenchymal transition(EMT) inrats withadenine-in-duced tubulointerstitial fibrosis .Methods Tubulointerstitial fibrosis ani mal models were established and SDrats were dividedinto mo-del group (n=30) ,treatment group (n=30) andcontrol group(n=30) ,randomly .Experi mental rats were harvested at 7 w,12 w,17 wafter onset of experi ment and functional evaluations were performed. Histology ,i mmunohistology were examined to investigateboth histolopathology changes and the expression of bone morphogenic protein-7 (BMP-7) ,transforming growth factor-?1(TGF-?1)and a-smooth muscle actin (?-SMA) in kidneys at three ti me points mentioned above ,respectively .Results Compared with controlgroup ,24 h urinary proteinin model grouplost increasingly and significantly difference appeared at three ti me points relative to controlgroup(P0 .05) rel-ative to control group.There was significant difference at 12 wand 17 w(P
