Protective Effect of Progesterone on Brain Edema in Newborn Rats with Hypoxic-Is chemic Encephalopathy
- VernacularTitle:孕酮对新生鼠缺氧缺血性脑病脑水肿的保护作用
- Author:
xiao-yin, WANG
;
chun-peng, ZHAO
;
dong-liang, LI
;
xue-peng, GUO
- Publication Type:Journal Article
- Keywords:
progesterone;
hypoxic-ischemic entepholopathy;
neonatal rats;
brain edema
- From:Journal of Applied Clinical Pediatrics
2004;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the protective effect of progesterone on brain edema in newborn rats with hypoxic-ischemic encephalopathy(HIE).Methods Fifty-two 7-day-old neonatal rats were randomly divided into 5 groups:normol control group(group A),hypoxic-ischemic group (group B) and pretreatment groups(group C,D and E).Rats were subjected to left common carotid artery ligation,then were exposed to 8% oxygen and 92% nitrogen for 2.5 hours to establish HIE model.Progesterone was injected intraperitoneally into the groups C,D and E rats respectively at 30 minutes before hypoxia.All rats were killed at the 24 hours after operations,then the contents of water,sodium,potassium were mensurated. Results The contentation of water in group B was higher than that in group A,the contentation of water,sodium in groups C,D and E were significantly lower compared with group B, but the contents potassium were no difference between group C,E and B. Conclusion Progesterone exerts a prominent preventive and protetive effects on the hypoxic ischemic brain edema in newborn rats.
