Study on Cellular Immune Function in Kawasaki Disease
- VernacularTitle:细胞免疫功能在川崎病发病机制中的作用
- Author:
shu-mei, ZHENG
;
wen-bin, LIU
;
tai-sen, WANG
;
hong-wei, ZHANG
;
ying, ZHOU
- Publication Type:Journal Article
- Keywords:
Kawasaki disease;
T lymphocyte subcytes;
interleukin 2;
interleukin-2 receptors
- From:Journal of Applied Clinical Pediatrics
2004;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the cellular immune function in children with kawasaki disease(KD).Methods T lymphocyte subcytes,levels of serum interleukin 2(IL-2) and soluble interleukin 2 receptor(sIL-2R) were determined by APAAP,ELISA met-hods,and a double-antibody “sandwich” enzyme-linked immunosorbent assay respectively in 60 cases.Results During the acute stage of KD,the percentage of CD4 +,the ratio of CD4 +/CD8 +,levels of IL-2 and sIL-2R increased markedly,while the percentage of CD3 + and CD8 + decreased significantly compared with the controls.These changes were more remarkable in patients subsequently developed coronary artery aneurysms than in those with normal appearing coronary artery.Conclusion Marked activation of cellular immune function and immune regulation disorders develop in acute stage of KD patients.
