Influence of Recombinant Human Growth Hormone Replacement Therapy on Glucose Metabolism in Children with Growth Hormone Deficiency
- VernacularTitle:重组人生长激素替代治疗对生长激素缺乏症患儿糖代谢的影响
- Author:
jin-tao, LIANG
;
tang, LI
- Publication Type:Journal Article
- Keywords:
recombinant human growth hormone;
glucose metabolism;
growth hormone deficiency;
children
- From:Journal of Applied Clinical Pediatrics
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of recombinant human growth hormone(r- hGH)replacement therapy on glucose metabolism in children with growth hormone deficiency(GHD) Methods Replacement therapy with domestic r - hGH was done in 15 children with GHD for 3 months. Oral glucose tolerance test (OGTT) and insulin .releasing test (IRT) were performed before and after 3 months of r-hGH replacement therapy. Venous blood was sampled before and 30,60,120 min after glucose load for measurements of plasma glucose (PG) and insulin (INS).Results OGTT were normal in 15 patients before treatment. After 3 months of r-hGH therapy, fasting plasma glucose remained unchanged, but PG 30 min(P
