Effects of Clara Cell Secretary Protein in Modulating Lung Inflammatory and Immune Responses to Respiratory Syncytial Virus Infection
- VernacularTitle:呼吸道立方形上皮细胞分泌蛋白对呼吸道合胞病毒肺部感染和免疫调节的作用
- Author:
yue-qun, MI
;
yi-xiao, BAO
;
ya-zhong, ZHU
- Publication Type:Journal Article
- Keywords:
clara cell secretary protein;
cytokine;
inflammation;
gene knockout
- From:Journal of Applied Clinical Pediatrics
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine a possible role for Clara cell secretary protein(CCSP)during acute RSV infection.Method CCSP-deficient [CCSP (-/-)]and wild-type (WT) mice were intratracheally infected with RSV and the lung inflammatory response to RSV infection were assessed.Results RSV-F gene expression increased in the lungs of CCSP (-/-) mice compared to WT mice following RSV infection, consistent with increased viral persistence. Lung inflammation was significantly worsened in CCSP (-/-) mice compared to WT mice after RSV infection. Th2 cytokines and neutrophil chemokines increased in the lungs of CCSP (-/-) mice following RSV infection.Conclusion These findings suggest that lack of CCSP may promote the inflammatory and Th2 immune response to RSV infection.
