Protective Effect of Ganciciovir on Acute Cerebral Injury of Mice Caused by Herpes Simplex Virus
- VernacularTitle:更昔洛韦对小鼠单纯疱疹病毒性急性脑损伤的保护作用
- Author:
xiao-yan, XU
;
jiu-lai, TANG
;
de, WU
;
shi-bing, YANG
- Publication Type:Journal Article
- Keywords:
herpes simplex virus;
brain injury;
pathology;
herpes simplex virus-1 copies;
ganciclovir;
mouse
- From:Journal of Applied Clinical Pediatrics
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effect and mechanism of ganciclovir(GCV) on acute cerebral injury of mice caused by herpes simplex virus(HCV). Methods Mice model of acute cerebral injury caused by HCV were established, morphological changes in the brain tissue of mouse treated with GCV were observed under the electronic microscope, and the mortality were compared. The HSV - I DNA copies of brain tissue were detected by fluorescent quantitative polymerase chain reaction. Results In the infected model group, there were obvious swelling, karyopyknosis and destruction of the structure in the brain cells, as well as myelin sheath solution and vacuolar degeneration in the mitochondrion and crest were destroyed. There were the virions in the nucleolus. With the GCV treatment, the symptoms were improved, the mortality much lowered, the yields of HSV - I DNA much lower. Conclusions GCV may restrain replication of HSV-Ⅰ effectively and lower the mortality of mice with acute cerebral injury caused by herpes simplex virus significantly.
