Expression of Macrophage Inflammatory Protein 2 in Brain Edema Caused by Lioposacchride in Rats
- VernacularTitle:巨噬细胞炎症蛋白2在脂多糖致大鼠脑水肿中的表达
- Author:
zhi-hong, ZHUO
;
xiao-ming, ZHAO
;
huai-li, WANG
;
tie-zheng, GAO
- Publication Type:Journal Article
- Keywords:
lioposacchride;
brain edema;
macrophage inflammatory protein 2
- From:Journal of Applied Clinical Pediatrics
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of macrophage inflammatory protein 2(MIP-2) and the interfering effects of naloxone in the brain edema caused by lioposacchride (LPS)in rats.Methods Eithty-four SD rats were randomly divided into 3 groups:normal saline group(NS group,n=28) 0.2 mL normal saline was injected by carotid into each rat;LPS group(n=28) with 200 ?g LPS;naloxone interfering group(NAL group,n=28)1 mg/kg naloxone was intraperitoneally injected at 10 min,1,2,6,12 h and following LPS injected 2 h before decapitation.The content of MIP-2 and even blue(EB) in brain tissue were detected at different time point.The brain water content was measured by drying method.Results The content of water and EB in LPS group were significan higher than those in NS group(P
