Protective Effects of Prostaglandin E_1 on Newborn Rats with Hypoxic-ischemic Brain Damage
- VernacularTitle:前列腺素E_1对新生大鼠缺氧缺血性脑损伤的保护作用
- Author:
chun-hua, XU
;
zheng-yong, JIN
;
hong-zi, LI
;
yong-xue, CHI
;
zhen-ai, JIN
- Publication Type:Journal Article
- Keywords:
superoxide dismutase;
nitric oxide;
prostaglandin E 1;
cerebral hypoxia;
cerebral ischemia
- From:Journal of Applied Clinical Pediatrics
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of exogenous prostaglandin E 1 (PGE 1) on the superoxide dismutase(SOD) and nitric oxide(NO) levels in brain tissue of neonatal rats with hypoxic-ischemic brain damage(HIBD).Methods Sixty 7-day old newborn Wistar rats to establish HIBD models,intraperitoneally and subcutaneous injected PGE 1 and TMP,then the rats were killed after hypo- xia and ischemia for 48 hours.Take cerebral cortex of arteria carotis ligation side and made them into homogenate to detect SOD and NO levels in brain tissue.Results SOD level in HIBD group was lower,and NO level was higher than those of normal group(P
