Changes of Transforming Growth Factor-?_1 and Vascular Endothelial Growth Factor in Children with Primary Nephrotic Syndrome
- VernacularTitle:肾病综合征患儿激素治疗前后转化生长因子?_1和血管内皮细胞生长因子的变化
- Author:
xue, ZHAO
;
xiu-qiao, TIAN
;
hui-feng, ZHANG
;
zhi-yan, DOU
- Publication Type:Journal Article
- Keywords:
nephrotic syndrome;
prednison;
transforming growth factor- beta 1;
vascular endothelial growth factor
- From:Journal of Applied Clinical Pediatrics
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change of serum transforming growth factor(TGF)-?1 and vascular endothelial growth facter( VEGF) in children with different types of primary nephrotic syndrome( PNS). Methods Children involved in the experiments were divided into simple type group, 16 cases; nephrit was type group, 16 cases, collecting blood sample in prednison - pretreated stage and in prednison- treated stage;control group, 14 cases. Monoclonal EUISA detected TGF-?1 and VEGF. Results Serum level of TGF-?1 and VKGF in active stage of simple type were higher than those of remission stage. The level in nephritis type was no signifi cant difference between prednison- treated stage and prednison - pretreated stage. The level in nephritis type was significantly higher than that in simple type. Conclusion Monitoring the dynamic change of serum TGF-?1 and VEGF can assess the effect of prednison treatment,and evaluate the prognosis of nephrotic syndrome.
