Effect of ligustrazine on the changes of collagen and expression of transforming growth factor - ?1 in airway wall of asthmatic rats
- VernacularTitle:川芎嗪对哮喘大鼠气道壁胶原沉积和转化生长因子-?_1表达的影响
- Author:
li, YANG
;
wen jian, WANG
;
xi-hua, WANG
;
hai-lang, LI
- Publication Type:Journal Article
- Keywords:
ligustrazine;
asthma;
collagen;
transforming growth factor ?1
- From:Journal of Applied Clinical Pediatrics
2004;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of ligustrazine on the changes of collagen, transforming growth factor- ?1(TGF- ?1) content in airway wall of asthmatic rats. Methods Forty SD rats were randomly divided mto normal group,model group, desametha-sone group, low - dose and high - dose of ligustrazine group, 8 rats in each group. The changes of collagen and TGF - ?1 content in the atrway wall were measured by the computerized image analysis system. Results The contents of collagen type Ⅲ and TGF -?1 in air-way wall in model group were significantly higher than controls group(P ail
