Effects of Intravenous Immunoglobulin on Apoptosis and Necrosis of Myocytes in Viral Myocarditis
- VernacularTitle:静脉滴注人血免疫球蛋白对病毒性心肌炎心肌细胞凋亡与坏死的影响
- Author:
jian-xin, ZHUANG
;
pei-ran, MA
;
yu-lin, WANG
;
qiu-bo, LI
;
hai-yan, XU
;
yong-hui, YU
- Publication Type:Journal Article
- Keywords:
myocarditis;
apoptosis;
intravenous immunoglobulin;
myocytes;
necrosis
- From:Journal of Applied Clinical Pediatrics
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of intravenous immunoglobulin(IVIG) on apoptosis and necrosis of myocytes in mice with viral myocarditis.Methods Three hundreds and twenty Balb/c mice were randomly divided into 8 groups.Different courses of IVIG were given in varying time after virus inoculation,Chinese medicine Huangqi given in control group.The virus titer in myocardium、percentage of apoptosis and necrosis of myocytes were detected, myocardial histopathologic scores were counted.Results In every IVIG treatment group,the above 3 items were all significantly lower than that in virus control group and Huangqi group,as IVIG early long course group had the best effect.Conclusion IVIG may reduce the percentage of apoptosis and necrosis of myocytes and virus titer in myocardium in mice with viral myocarditis,the effects are better than that of Huangqi.
